Wil Zoloft Work Fast if Taking Again

Brand name: Zoloft®

  • Tablets: 25 mg, 50 mg, 100 mg
  • Liquid: twenty mg/mL


Generic proper noun: sertraline (SER tra leen)

All FDA black box warnings are at the end of this fact canvass. Please review earlier taking this medication.

What Is Sertraline And What Does It Care for?

Sertraline is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder (MDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder. It is as well approved to treat obsessive-compulsive disorder (OCD) in adults, children and adolescents aged 6-17 years.

Symptoms of depression include:

  • Depressed mood - feeling sad, empty, or bawling
  • Feeling worthless, guilty, hopeless, and helpless
  • Loss of interest or pleasure in your usual activities
  • Sleep and eat more or less than usual (for most people it is less)
  • Low free energy, problem concentrating, or thoughts of expiry (suicidal thinking)
  • Psychomotor agitation ('nervous energy')
  • Psychomotor retardation (feeling similar you are moving and thinking in slow motion)
  • Suicidal thoughts or behaviors


PTSD occurs when a person experiences a traumatic event (east.g., assault, combat experience) and then later feels on edge; avoids situations that remind them of the result; and experiences flashbacks or nightmares.

PMDD is a condition where a woman experiences depression, tension, and irritability for a few days prior to flow that end when menstruation begins. These symptoms are more astringent than those of premenstrual syndrome (PMS).

Panic Disorder occurs when a person experiences unexpected and repeated episodes of intense fear. These episodes take concrete symptoms including chest pain, shortness of breath, heart palpitations, sweating, dizziness, and nausea. Fear of future episodes is also part of panic disorder.

Obsessive Compulsive Disorder (OCD) occurs when a person experiences the post-obit symptoms at the same fourth dimension:

  • Obsessions (unwanted, recurrent, and disturbing thoughts)
  • Compulsions (repetitive, ritualized behaviors that the person feels driven to perform in society to lessen the anxiety produced by the obsessions)


Social phobia/social anxiety disorder is a fear of situations where one may feel as if they are existence judged by others. Symptoms include:

  • Blushing
  • Difficulty talking
  • Nausea
  • Sweating
  • Shaking


Sertraline may also be helpful when prescribed "off-label" for rampage-eating disorder, bulimia nervosa, and generalized anxiety disorder (GAD). "Off-label" means that it hasn't been approved by the Nutrient and Drug Administration for this condition. Your mental health provider should justify his or her thinking in recommending any "off-label" treatment. They should be clear nearly the limits of the research around that medication and if there are whatsoever other options.

What Is The Nigh Of import Data I Should Know About Sertraline?

Do non stop taking sertraline, even when you feel meliorate. With input from yous, your health intendance provider will assess how long you will demand to have the medicine.

Missing doses of sertraline may increase your risk for relapse in your symptoms.

Stopping sertraline abruptly may consequence in i or more than of the following withdrawal symptoms: irritability, nausea, feeling dizzy, vomiting, nightmares, headache, and/or paresthesias (prickling, tingling sensation on the skin).

Depression is also a part of bipolar disease. People with bipolar disorder who accept antidepressants may exist at risk for "switching" from low into mania. Symptoms of mania include "high" or irritable mood, very high cocky-esteem, decreased need for sleep, pressure to go on talking, racing thoughts, existence easily distracted, frequently involved in activities with a large gamble for bad consequences (for instance, excessive buying sprees).

Medical attention should be sought if serotonin syndrome is suspected. Please refer to serious side furnishings for signs/symptoms.

Are There Specific Concerns Nearly Sertraline And Pregnancy?

If you are planning on becoming pregnant, notify your health care provider to best manage your medications. People living with MDD who wish to become pregnant face up of import decisions. Untreated MDD has risks to the fetus, also as the mother. It is of import to discuss the risks and benefits of treatment with your doctor and caregivers. For women who take antidepressant medications during weeks xiii through the end of their pregnancy (2nd and 3rd trimesters), there is a risk that the baby can be born earlier it is fully developed (before 37 weeks).

For mothers who have taken SSRIs during their pregnancy, at that place appears to be less than a one% chance of infants developing persistent pulmonary hypertension. This is a potentially fatal status that is associated with utilise of the antidepressant in the second half of pregnancy. All the same, women who discontinued antidepressant therapy were v times more than likely to have a low relapse than those who connected their antidepressant. If you are pregnant, please discuss the risks and benefits of antidepressant use with your wellness care provider.

Caution is advised with breastfeeding since sertraline does laissez passer into chest milk.

What Should I Talk over With My Health Care Provider Before Taking Sertraline?

  • Symptoms of your status that bother you the most
  • If you take thoughts of suicide or harming yourself
  • Medications y'all take taken in the past for your condition, whether they were effective or caused any agin furnishings
  • If yous feel side effects from your medications, discuss them with your provider. Some side effects may pass with time, just others may crave changes in the medication.
  • Any other psychiatric or medical problems you lot have, including a history of bipolar disorder
  • All other medications you are currently taking (including over the counter products, herbal and nutritional supplements) and any medication allergies you have
  • Other non-medication treatment y'all are receiving, such as talk therapy or substance corruption treatment. Your provider can explain how these different treatments work with the medication.
  • If you lot are pregnant, plan to go meaning, or are breastfeeding
  • If you drink alcohol or utilize drugs


How Should I Take Sertraline?

Sertraline is usually taken one time per day with or without nutrient.

Typically patients begin at a low dose of medicine and the dose is increased slowly over several weeks.

The dose usually ranges from 50 mg to 200 mg. Simply your health care provider tin can determine the correct dose for you.

If you are taking it for PMDD, sertraline tin be taken once daily (everyday) or intermittently (usually starting 14 days prior to menstruation through the kickoff full solar day of menses of each cycle).

The liquid should be measured with an oral syringe or dropper which yous can become from your pharmacy. It should exist added to 4 ounces of water, ginger ale, lemon/lime soda, lemonade, or orange juice immediately prior to taking the medication. Information technology should non be mixed in advance.

Consider using a agenda, pillbox, alert clock, or cell telephone alert to help yous remember to take your medication. You may besides ask a family fellow member or friend to remind you or cheque in with y'all to be certain yous are taking your medication.

What Happens If I Miss A Dose Of Sertraline?

If you miss a dose of sertraline, have information technology every bit soon equally you remember, unless it is closer to the fourth dimension of your next dose. Discuss this with your health care provider. Practice not double your adjacent dose or take more than what is prescribed.

What Should I Avoid While Taking Sertraline?

Avoid drinking alcohol or using illegal drugs while yous are taking antidepressant medications. They may decrease the benefits (e.m., worsen your condition) and increase agin effects (e.g., sedation) of the medication.

What Happens If I Overdose With Sertraline?

If an overdose occurs, phone call your doctor or 911. You may need urgent medical care. Yous may also contact the poisonous substance control center at one-800-222-1222.

A specific treatment to reverse the effects of sertraline does not exist.

What Are The Possible Side Furnishings Of Sertraline?

Mutual side effects

  • Headache, nausea, diarrhea, dry out oral fissure, increased sweating
  • Feeling nervous, restless, fatigued, sleepy or having problem sleeping (insomnia)

These will oft improve over the first week or two as you continue to take the medication.

Sexual side effects, such as problems with orgasm or ejaculatory delay often do not diminish over time.

Rare/serious side effects

Low sodium blood levels (symptoms of low sodium levels may include headache, weakness, difficulty concentrating and remembering), teeth grinding, bending closure glaucoma (symptoms of bending closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye).

Serotonin syndrome (symptoms may include shivering, diarrhea, defoliation, severe muscle tightness, fever, seizures, and death), seizure

SSRI antidepressants including sertraline may increment the risk of bleeding events. Combined use of aspirin, nonsteroidal anti-inflammatory drugs (due east.thousand., ibuprofen, naproxen), warfarin, and other anti-coagulants may increase this risk. This may include gums that bleed more easily, nose bleed, or gastrointestinal haemorrhage. Some cases have been life threatening.

Are There Any Risks For Taking Sertraline For Long Periods Of Fourth dimension?

To engagement, in that location are no known problems associated with long term use of sertraline. It is a safe and effective medication when used as directed.

What Other Medications May Collaborate With Sertraline?

Sertraline should non be taken with or inside 2 weeks of taking monoamine oxidase inhibitors (MAOIs). These include phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), rasagiline (Azilect®), and selegiline (Emsam®).

Although rare, there is an increased run a risk of serotonin syndrome when sertraline is used with other medications that increment serotonin, such as other antidepressants, migraine medications called "triptans" (e.1000., Imitrex®), some hurting medications (east.g., tramadol (Ultram®)), and the antibiotic linezolid (Zyvox®).

Sertraline should not exist taken with pimozide (Orap®).

Sertraline may increase the effects of other medications that can crusade bleeding (e.g., ibuprofen (Advil®, Motrin®), warfarin (Coumadin®) and aspirin).

Sertraline liquid should Non be taken in combination with disulfiram (Antabuse®) due to the booze content of the concentrate.

How Long Does It Take For Sertraline To Work?

Sleep, energy, or appetite may testify some improvement within the starting time i-2 weeks. Improvement in these concrete symptoms tin exist an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-eight weeks to fully improve.

Summary of FDA Black Box Warnings

Suicidal thoughts or actions in children and adults

Low and certain other psychiatric disorders are themselves associated with increases in the take a chance of suicide. Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and beliefs (suicidality) or unusual changes in beliefs, whether or not they are taking antidepressant medications. This risk may persist until significant remission occurs.

In short-term studies, antidepressants increased the hazard of suicidality in children, adolescents, and young adults when compared to placebo. Brusk-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. Adults age 65 and older taking antidepressants have a decreased adventure of suicidality. Patients, their families, and caregivers should exist alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient'due south prescriber or health intendance professional person. All patients being treated with antidepressants for any indication should watch for and notify their health care provider for worsening symptoms, suicidality and unusual changes in behavior, peculiarly during the first few months of handling.

Provided by

(Dec 2020)

©2020 The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Disease (NAMI). CPNP and NAMI make this document bachelor under the Creative Commons Attribution-No Derivatives 4.0 International License. Terminal Updated: January 2016.

This information is being provided equally a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. This information is for educational and advisory purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. E'er seek the advice of a physician or other qualified medical professional person with any questions you may have regarding medications or medical conditions. Never filibuster seeking professional medical communication or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability declared as a event of the information provided herein.

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Source: https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Sertraline-%28Zoloft%29

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